[关键词]
[摘要]
目的 研究新鲜狼毒大戟Euphorbia fischeriana地上部分的化学成分。方法 采用硅胶柱色谱、高效液相及重结晶等方法进行分离纯化,通过波谱分析的方法鉴定化合物结构。结果 从新鲜狼毒大戟地上部分甲醇提取液正己烷萃取物中分离得到14个化合物,分别鉴定为23(E)-25-methoxycycloart-23-en-3β-ol(1 )、24-hydroperoxycycloart-25-en-3β-ol(2 )、25-hydroperoxycycloart-23-en-3β-ol(3 )、羽扇豆醇(4 )、24-亚甲基环阿尔廷醇(5 )、大戟醇(6 )、24-methylenecycloartane-3, 28-diol(7 )、钝叶甾醇(8 )、叶绿醇(9 )、jolkinolide A(10 )、2, 4-二羟基-6-甲氧基-3-甲基苯乙酮(11 )、24-亚甲基-9, 19-环-3-羊毛甾酮(12 )、12-去氧佛波醇-13-十六酸酯(13 )、butyrospermol(14 )。结论 其中化合物9 为首次从该属植物中分离得到,化合物1~3、7、8 为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the aerial part of fresh Euphorbia fischeriana. Methods Fourteen compounds were isolated and purified by silica gel column chromatography, HPLC and recrystallization methods, and their structures were identified by spectral analysis. Results Fourteen compounds were isolated and identified as 23 (E)-25-methoxycycloart-23-en-3β-ol (1 ), 24-hydroperoxycycloart-25-en-3β-ol (2 ), 25-hydro-peroxycycloart-23-en-3β-ol (3 ), lupeol (4 ), 24-methylenecycoartanol (5 ), euphol (6 ), 24-methylenecycloartane-3, 28-diol (7 ), obtusifoliol (8 ), phytol (9 ), jolkinolide A (10 ), 2, 4-dihydroxy-6-methoxy-3-methyl-1-acetophenone (11 ), 3-oxo-24-methylenecycloarane (12 ), 12-deoxyphorbol-13-hexadecanoate (13 ), and butyrospermol (14 ). Conclusion Compound 9 is obtained from the plants in Euphorbia L. for the first time, and compounds 1—3 and 7—8 are isolated from E. fischeriana for the first time.
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[基金项目]
黑龙江省自然科学基金面上项目(B201209);黑龙江省教育厅青年学术骨干项目(1253G064)