雷公藤作为治疗类风湿性关节炎等自身免疫性疾病的首选药，其所含化学成分复杂，具有抗炎、抗肿瘤、免疫调节及抗生育等作用，是目前国内外研究的热点天然药物之一。但在使用中雷公藤所引起的肝损伤报道频繁发生，大大限制了其临床应用。依据“异类相制”的中药配伍理论，对雷公藤肝毒性减毒方面的有关文献进行归类分析，提出雷公藤肝毒性配伍减毒的组方原则，以期为提高雷公藤临床应用的安全性提供参考。

Tripterygium wilfordii as the preferred treatment drug for autoimmune diseases such as rheumatoid arthritis, with complicated chemical composition and anti-inflammatory, antitumor, immune regulation, and anti-reproductive function, is one of the hot natural medicines both at home and abroad. However, liver damage caused by T. wilfordii is reported frequently, which greatly limits its clinical application. In this paper, we collect and summarize the researches on the hepatotoxicity and compatibility of T. wilfordii in recent years based on the "detoxicity compatibility" theory of Chinese medicine compatibility. Meanwhile, we propose the principle of prescription to reduce the hepatotoxicity of T. wilfordii by compatibility mechanism, with a view to improve the security of the clinical application of T. wilfordii.

国家科技支撑计划“新安医学民方验方筛选评价研究”课题（2012BA126B03）；安徽省科技厅2010年重点实验室计划项目（10111406029）