目的 研究甘草苷在大鼠体内的代谢途径。方法 大鼠ig给予甘草苷300 mg/kg后，收集胆汁、尿液、粪便和血浆，应用高效液相色谱-四级杆-离子阱串联质谱(HPLC-QTRAP-MS)技术分析甘草苷在大鼠体内的代谢途径。结果 共检测到除原形药物外的9个代谢产物，提示甘草苷在大鼠体内的主要代谢途径为脱葡萄糖基反应生成甘草素及甘草素的脱氢氧化以及葡糖醛酸化和硫酸化。结论 甘草苷在大鼠体内经历了广泛的I相和II相代谢。应用峰面积归一化法计算主要代谢产物相对生成量百分比，甘草苷ig给药后在大鼠胆汁、尿、粪和血浆中的主要代谢产物为甘草素、甘草素的葡萄糖醛酸结合物及其硫酸结合物。

Objective To study the in vivo metabolic pathways of liquiritin (LQ) in rats. Methods An HPLC-QTRAP-MS method was established and applied to identify the metabolites of LQ in bile, urine, feces, and plasma after ig administration of LQ (300 mg/kg) to rats. Results A total of nine metabolites were found in rats. The major metabolic pathway of LQ was deglucosidation to liquiritigenin (LG) and dehydration, glucuronidation, and sulfation of LG. Conclusion LQ undergoes extensive phases I and II metabolism in rats. The major metabolites of LQ are LG and its glucuronides and sulfates.