[关键词]
[摘要]
目的 研究列当科药用植物弯管列当Orobanche cernua全草的化学成分。方法 利用大孔树脂、硅胶、MCI、SephadexLH-20等柱色谱技术分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果 从弯管列当全草70%乙醇提取物分离鉴定了12个化合物,其中8个为苯乙醇苷类:阿克苷(1)、campneoside II(2)、crenatoside(3)、campneoside I(4)、isocrenatoside(5)、异阿克苷(6)、leucosceptoside A(7)和肉苁蓉苷F(8);3个为木脂素类:丁香脂素-4'-O-β-D-葡萄糖苷(9)、连翘脂素-4'-O-β-D-葡萄糖苷(10)和isoeucommin A(11);1个为甾醇类:豆甾醇-3-O-β-D-葡萄糖苷(12)。结论 化合物7和12为首次从列当科植物中分离得到;4、7、9~12为首次从列当属植物中分离得到,2、4、6~12为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Orobanche cernua in Orobanchaceae. Methods The chemical constituents were separated and purified by macroporous resin, silica gel, Sephadex LH-20, and MCI column chromatographies. Their structures were determined by physicochemical properties and spectral data. Results Twelve compounds were isolated from 70% ethanol extract of O. cernua. Among them, eight phenylpropanoid glycosides were identified as acteoside (1), campneoside II (2), crenatoside (3), campneoside I (4), isocrenatoside (5), isoacteoside (6), leucosceptoside A (7), and cistanoside F (8), three liganans were identified as (+)-syringaresinol-4'-O-β-D-glucopyranoside (9), (+)-pinoresinol-4'-O-β-D-glucopyranoside (10), and isoeucommin A (11), and one steroide was stigmasterol-3-O-β-D-glucoside (12). Conclusion Compounds 7 and 12 are isolated from the family Orobanchaceae for the first time; Compounds 4, 7, and 9—12 are isolated from the plants of Orobanche L. firstly, and compounds 2, 4, and 6—12 are found from O. cernua for the first time.
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[基金项目]
国家自然科学基金资助项目(81260615);内蒙古自治区自然科学基金资助项目(2010BS1202)