目的 建立中药复方提取过程中成分变化信息分析方法——指纹图谱段带总量统计矩法。方法 运用指纹图谱段带统计矩法分析黄连解毒汤指纹图谱信息，阐述中药复方提取过程中成分变化情况。结果 黄连解毒汤煎煮160 min后成分基本趋于稳定。黄连解毒汤合煎与单味药提取过程相比，某些成分被抑制，某些成分被促进，亦可能有新成分的出现。结论 指纹图谱段带统计矩法可用于中药复方提取过程中成分变化信息及中药复方提取时间的研究。

Objective To establish a new analytical method of ingredients transformation during the Chinese material medica (CMM) compound extraction: chromatographic fingerprints division total quantum statistical moment (CFDTQSM) method. Methods The expression was set up by CFDTQSM method in order to analyze the fingerprint information of Huanglian Jiedu Decoction (HJD), and to explain the ingredients transformation during the CMM compound extraction. Results It has been concluded by studying the extracting solution of HJD that the ingredients were stabilized after decocting for 160 min. And compared with the extraction process of single herb, some ingredients are restrained in HJD, some are advanced and some new ingredients are produced. Conclusion The CFDTQSM method could be used to the study on the ingredients transformation during the CMM compound extraction, and the study on extraction time.

国家自然科学基金项目（81173558，81270055）；高等学校博士学科点基金博导类项目（20124323110002）；湖南省自然科学基金项目（13JJ5032，11JJ2055）；湖南省中医药科研计划项目（201494）；湖南省“十二五”省级药学重点学科项目（1007）