逍遥散有明确的抗抑郁作用，但其作用机制尚不清楚。从神经递质、神经营养素、下丘脑-垂体-肾上腺轴、氨基酸、脂质和能量代谢以及炎症因子等方面对逍遥散抗抑郁机制进行分析，归纳总结了逍遥散抗抑郁的代谢网络调控机制。结果显示逍遥散作用于多个靶点，通过调节体内代谢平衡发挥抗抑郁作用。

The anti-depressive effect of Xiaoyaosan is obvious; However, the potential mechanism remains unclear. This paper elucidated the antidepressive mechanism of Xiaoyaosan from the fields of neurotransmitter, neurotrophins, hypothalamic-pituitary- adrenal axis, metabolisms of amino acid, lipid, and energy, inflammatory factor, and metabolic network figure. The comprehensive results implicate that Xiaoyaosan plays as antidepressant via the role of action on multiple targets and regulation in the metabolic balance in vivo.

国家自然科学基金资助项目（81173366，81102833）；国家“重大新药创制”科技重大专项课题（2012ZX09103201-035）；国家国际科技合作计划项目（2011DFA32630）；山西省科技计划项目（2012021031-2，20130313015-1）