目的 制备水蜈蚣Kyllinga blevifolia总黄酮固体分散体，以提高其体外溶出率。方法 分别以聚乙烯吡咯烷酮K30（PVP K30）、聚乙二醇（PEG）6000、PEG 4000、泊洛沙姆188（F68）为载体，采用溶剂法或溶剂熔融法制备固体分散体，考察其体外释药性能，并利用扫描电子显微镜（SEM）、红外光谱（IR）等表征手段对固体分散体的结构特征进行分析研究。结果 以PVP K30为载体制备的固体分散体的体外溶出率优于其他载体制备的固体分散体，且以药物-载体比例1：2为最佳。SEM与IR结果表明，固体分散体中药物以无定形形式存在于载体中。结论 固体分散体技术能显著提高水蜈蚣总黄酮的体外溶出度。

Objective To prepare the solid dispersion of Kyllinga brevifolia total flavonols (KBTF) for improving the dissolution rate of KBTF. Methods The solid dispersion was prepared by the melted and dissolved method with the carriers of PVP K30, PEG 6000, PEG 4000, and Poloxamer 188 and the in vitro dissolution of KBTF solid dispersions was performed. The structure of the solid dispersion was characterized by SEM and IR. Results The solid dispersion prepared with PVPK30 as carrier is better to improve the dissolution than those with other carriers, and drug-carrier (1:2) is the best. The results of SEM and IR showed that KBTF in solid dispersion took amorphous form. Conclusion The solid dispersion technology can significantly increase the dissolution of KBTF in vitro.

国家“重大新药创制”科技专项（2009zx09103-355，2012zx0910220l-006）