目的 研究大鼠口服α-常春藤皂苷后粪便中的代谢产物。方法 大鼠ig α-常春藤皂苷150 mg/kg后，采集其0～24 h粪便样品，应用超高效液相色谱-复合三重四级杆线性离子阱质谱（UPLC-Q/Trap-MS）联用技术对样品进行分析。结果 检测到原形药物、原形药物的同分异构体及7个可能的代谢产物，包括去甲基化代谢物（M1）、脱糖代谢物（M2、M3）、葡萄糖醛酸化代谢物（M4）和双键加成代谢物（M5、M6-1、M6-2）。结论 α-常春藤皂苷在大鼠胃肠道内会发生多种代谢反应，主要有脱糖代谢、葡萄糖醛酸化代谢、去甲基化代谢等。

Objective To investigate the metabolites of α-hederin in feces of rats after ig administration. Methods An UPLC- Q/Trap-MS method was used for the identification of metabolites of α-hederin in feces of rats after ig administration of α-hederin (150 mg/kg). Results Seven metabolites were detected in rat feces, including demethylation of α-hederin (M1), 3-O-α-L- arabinopyranoside hederagenin (M2), hederagenin (M3), glucuronideconjugate of α-hederin (M4), and double bond bonus of α-hederin (M5, M6-1, and M6-2). Conclusion α-Hederin experiences a variety of metabolic reactions in rat gastrointestinal tract, mainly including deglycosylation, glucuronidation, demethylation, etc.

国家“重大新药创制”科技重大专项（2012ZX09103201-008）；江西省卫生厅中医药科研项目（2012A028）；南昌市科技支撑计划（洪财企 [2012]80号社发支撑-3）；贵州省药物代谢研究平台建设项目（黔科合ZY [2011] 3013号）；贵州省科技创新人才团队建设项目（黔科合人才团队（2011）4008）