多成分药物代谢是以多成分中各成分间的转运蛋白相互影响及药物代谢酶相互影响为核心，以多成分同时测定为原则，以多成分环境影响的代谢变化为重点研究方向，其理论内容由序贯代谢、并发代谢、多重代谢组成，在坚持多成分同时测定、代谢连续时间记录、代谢连续空间记录及定性与定量结合的研究原则下，综合运用体内实验、在体实验及离体实验方法开展研究。在直观比较分析与量化数据评价的模式下，可认为多成分药物代谢是学术基础扎实、技术手段先进的新兴科研方向。

The core of multicomponent drug metabolism is the mutual influence of the transporters and drug metabolic enzymes interaction of more ingredients, with the simultaneous determination for multiple components as the principle, and with many components changes on the environmental impact as the emphasis. Its theoretical content composes by sequential metabolism, concurrent metabolism, and multiple metabolism. On the principles of multicomponent simultaneous determination, metabolic continuous time records, metabolic continuous space records, and the combination of qualitative and quantitative research, the multicomponent drug metabolism is researched by the experimental methods of in vivo, in situ, and in vitro. In visual mode of the comparative analysis with the quantitative data evaluation, multicomponent drug metabolism can be thought of emerging research direction with solid academic foundation and advanced technical means.

国家自然科学基金资助项目（81274042，81303217）