目的 研究左归降糖解郁方对糖尿病并发抑郁症大鼠血糖、血脂的影响。方法 采用ig高脂乳剂、iv链脲佐菌素（STZ，38 mg/kg）和慢性应激联合的方法制备糖尿病并发抑郁症大鼠模型，并随机分为5组：模型组，阳性药（二甲双胍0.18 g/kg+百忧解1.8 mg/kg）组，左归降糖解郁方高、中、低剂量（20.53、10.26、5.13 g/kg）组，同时以正常大鼠为对照组。各组造模同时ig给药，共4周；生化法检测各组大鼠血糖、糖化血红蛋白水平、胰岛素抵抗及血脂水平，ELISA法测定大鼠血浆皮质酮水平，HE染色观察大鼠肾上腺的病理改变。结果 与对照组比较，模型组大鼠血糖、糖化血红蛋白、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、三酰甘油（TG）和血浆皮质酮水平显著升高，高密度脂蛋白胆固醇（HDL-C）水平显著降低（P<0.05），具有明显的胰岛素抵抗。给予左归降糖解郁方干预后，大鼠血糖、糖化血红蛋白、TC、TG、LDL-C水平显著降低，HDL-C水平显著升高，胰岛素抵抗程度减轻，血浆皮质酮水平明显降低（P<0.05、0.01），肾上腺损伤程度减轻。结论 左归降糖解郁方可改善糖尿病并发抑郁症大鼠的血糖、血脂异常，该作用可能与其保护肾上腺，降低循环系统皮质酮水平有关。

Objective To investigate the effects of Zuogui Jiangtang Jieyu Fang (ZJJF) on the blood glucose and blood lipids in diabetes mellitus (DM) rats with depression. Methods DM rat model with depression was established by the combination of high-fat diet, injection of Streptozotocin (STZ, 38 mg/kg), and chronic stress. The model rats were randomly divided into five groups, the DM with depression group, metformin (0.18 g/kg) combined fluoxetine (1.8 mg/kg) group, high-, mid-, and low-dose (20.53, 10.26, and 5.13 g/kg) ZJJF groups. After 4 weeks of administration, blood glucose, HbA1c, lipids, and insulin resistance (IR) were assayed by biochemical techniques. The corticosterone (CORT) level in plasma was detected by ELISA method. HE staining was used to observe the adrenal pathological changes of MD rats. Results Compared with the control group, the levels of blood glucose, HbA1c, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL-C) were significantly higher, and the level of high-density lipoprotein (HDL-C) was significantly lower. The CORT level in plasma was significantly higher (P <0.05). The significant pathological changes existed in adrenal gland were observed by HE staining. Compared with the model group, the blood glucose was significantly stable, IR, HbA1c, TC, TG, LDL-C, and CORT levels in plasma of rats in ZJJF group were significantly decreased, HDL-C level was significantly elevated, while the adrenal pathological changes were reduced. Conclusion The metabolic disorders of blood glucose and lipids could be improved by ZJJF, which might be correlated to the down-regulation of the CORT level for protecting the adrenal gland.

国家自然科学基金资助项目（81373578）；湖南省自然科学基金资助项目（13JJ5030）；湖南省科技厅科技计划项目（2012SK3141）；湖南省高校创新平台开放基金项目（13k074）