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[摘要]
目的 研究细叶杜香Ledum palustre全草的化学成分。方法 采用硅胶柱色谱和高效液相色谱法等分离方法,对细叶杜香正己烷萃取物的化学成分进行分离并经波谱数据分析鉴定化合物的结构。结果 从细叶杜香全草无水乙醇提取液正己烷萃取物中分离得到13个化合物,分别鉴定为大戟醇乙酰酯(1)、lanosta-8,24-dien-3-one(2)、蒲公英萜酮(3)、泪杉醇(4)、(24S)-豆甾-4-烯-3-酮(5)、大戟醇(6)、异海松酸(7)、醋酸落叶松酯(8)、28-羟基-羽扇豆酮(9)、β-谷甾醇(10)、异水菖蒲二醇(11)、古柯二醇(12)、熊果醇(13)。结论 化合物2、4~9、11、12为首次从杜香属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Ledum palustre. Methods Compounds were isolated from n-hexane fraction in the ethanol extract from L. palustre by silica gel column chromatography and HPLC. The structures of the chemical constituents were identified by analysis on their spectral data. Results Thirteen compounds were isolated from n-hexane fraction in the ethanol extract from L. palustre and identified as euphol acetate (1), lanosta-8, 24-dien-3-one (2), taraxerol (3), labda-8(17), 14-dien-13-ol (4), (24S)-stigmast-4-en-3-one (5), euphol (6), isopimaric acid (7), larixyl acetate (8), 28-hydroxyl-lupenone (9), β-sitosterol (10), isocalamendiol (11), erythrodiol (12), and uvaol (13). Conclusion Compounds 2, 4—9, 11, and 12 are first obtained from the plants of Ledum L.
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[基金项目]
黑龙江省普通高等学校新世纪优秀人才培养计划资助项目(1251-NECT-018)