目的 对刘寄奴Artemisiae Anomalae Herba（奇蒿Artemisia anomala或白苞蒿A. actiflora的干燥地上部分）进行化学成分研究。方法 采用硅胶柱色谱、Sephadex LH-20柱色谱和制备高效液相色谱等进行分离纯化，根据理化性质和波谱分析进行结构鉴定。结果 从刘寄奴中分离得到15个化合物，包括7个甾体和8个黄酮类化合物，分别鉴定为β-谷甾醇（1）、β-胡萝卜苷（2）、schleicheol 2（3）、α-菠甾醇（4）、3β-羟基-5α，8α-过氧-6，22-麦角甾二烯（5）、3β-羟基-5α，8α-过氧-6，9（11），22-麦角甾三烯（6）、22E-3β，5α-二羟基-麦角甾-7，22-二烯-6-酮（7）、柚皮素（8）、木犀草素（9）、山柰酚（10）、柯伊利素（11）、香叶木素（12）、棕矢车菊素（13）、异鼠李素-3-O-葡萄糖（14）、橙皮素-7-O-β-D-葡萄糖（15）。结论 化合物5、6、12～14为首次从该植物中分离得到，化合物3为首次从蒿属植物中分离得到，化合物7、15为首次从菊科植物中分离得到。

Objective To investigate the chemical constituents from Artemisiae Anomalae Herba (the aerial part of Artemisia anomala or A. actiflora). Methods The chemical constituents from Artemisiae Anomalae Herba were isolated and purified by chromatography on silica gel and Sephadex LH-20 column, as well as preparative HPLC. Their structures were identified on the base of physicochemical properties and spectroscopic data analyses. Results Fifteen constituents, including seven steroids and eight flavonoids, were isolated and identified as β-sitosterol (1), β-daucosterol (2), schleicheol 2 (3), α-spinasterol (4), 5α, 8α-epidioxy-ergosta-6, 22-dien-3β-ol (5), 5α, 8α-epidioxy-ergosta-6, 9(11), 22-trien-3β-ol (6), 22E-3β, 5α-dihydroxyergosta-7, 22-dien-6-one (7), naringenin (8), luteolin (9), kaempferol (10), chrysoeriol (11), diosmetin (12), jaceosidin (13), isorhamnetin 3-O-glucoside (14), and hesperetin-7-O-β-D-glucopyranoside (15). Conclusion Compounds 5, 6, 12—14 are isolated from this plant for the first time, compound 3 is isolated from the plants of Artemisia L. for the first time, and compounds 7 and 15 are isolated from the plants in Compositae family for the first time.

国家自然科学基金资助项目（21075127）；中科院重要方向性项目（KSCX2-EW-R-15）