[关键词]
[摘要]
目的 研究牛大力(美丽崖豆藤Millettia speciosa的干燥根)中的化学成分。方法 采用大孔吸附树脂、硅胶柱色谱、葡聚糖凝胶柱色谱和重结晶等分离方法进行分离纯化,综合运用各种波谱手段和理化性质鉴定各化合物的结构。结果 从牛大力95%乙醇提取物中分离纯化得到16个化合物,分别鉴定为7-羰基-β-谷甾醇(1)、橙黄胡椒酰胺乙酸酯(2)、紫菀酮(3)、顺丁烯二酸(4)、补骨脂素(5)、N-甲基金雀花碱(6)、咖啡酸羽扇豆醇酯(7)、双去氧基姜黄素(8)、香草酸(9)、丁香酸(10)、6-甲氧基二氢血根碱(11)、甘草酸(12)、(E)-3,3’-二甲氧基-4,4’-二羟基-1,2-二苯乙烯(13)、五味子醇乙(14)、7-羟基千金二萜醇(15)、苷松新酮(16)。结论 所有化合物均为首次从该植物中分离得到,其中化合物3、7、8、11、13~16为首次从该科植物中分离得到,化合物2、4~6、9、10为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the roots of Millettia speciosa (Leguminosae). Methods Compounds in the 95% ethanol extract from the air-dried roots of M. speciosa were isolated by chromatography on silica gel column together with recrystallization, and their structures were identified by their physicochemical characteristics and spectral features. Results Sixteen components were isolated from the air-dried roots of M. speciosa and identified as 7-oxo-β-sitosterol (1), aurantiamide acetate (2), shionone (3), maleic acid (4), psoralen (5), N-methylcytisine (6), lupeol caffeate (7), bisdemethoxycurcumin (8), vanillic acid (9), syringic acid (10), 6-methoxydihdyrosanguinarine (11), glycyrrhizic acid (12), (E)-3, 3'-dimethoxy-4, 4'-dihydroxystilbene (13), schisandrol B (14), 7-hydroxylathyrol (15), and nardosinone (16). Conclusion All the compounds are isolated from this plant for the first time, and compounds 3, 7, 8, 11, and 13—16 are isolated from the plants of Leguminosae for the first time, compounds 2, 4—6, 9, 10 are isolated from the plants of Millettia Wight et Arn. for the first time.
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[基金项目]
科技部“973”计划前期研究专项(2011CB512010);海南省自然科学基金资助项目(213019)