目的 探索丹参酮Ⅱ_A喷雾干燥粉体的药剂学性质。方法 采用喷雾干燥法处理丹参酮Ⅱ_A，并运用比表面积测定法（BET）、扫描电镜法（SEM）、差示扫描量热法（DSC）和X射线粉末衍射法（XRD）等方法对丹参酮Ⅱ_A粉体进行分析，考察其体外溶出度和稳定性。结果 BET结果显示经喷雾干燥处理后的丹参酮Ⅱ_A具有较窄的粒径分布范围及较大的比表面积；XRD和DSC分析结果显示部分丹参酮Ⅱ_A已转变为非晶形式；在8 h丹参酮Ⅱ_A的累积溶出度为85.2%。结论 喷雾干燥方法处理丹参酮Ⅱ_A有利于提高药物体外溶出度，为难溶性药物口服给药制剂的设计提供参考。

Objective To explore a method to improving the in vitro dissolution of tanshinone Ⅱ_A spray drying powder and to study its pharmceutical properties. Methods Tanshinone Ⅱ_A was processed with spray drying method and analyzed by determination of the specific surface area (BET), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD). And in vitro dissolution and drug stability were also investigated. Results The BET results showed that tanshinone Ⅱ_A powder after spray drying had narrow particle size distribution range and large specific surface area; XRD and DSC analyses showed that most drug was transformed into amorphous form. The in vitro dissolution achieved 85.2% within 8 h. Accelerating experiment showed that the in vitro dissolution of tanshinone Ⅱ_A decreased by approximately 21% stored for 6 months. Conclusion The drug dissolution is improved by spray-drying method. It provides a reference for the research and development of poorly soluble pharmaceutical preparations for oral administration.

国家自然科学基金资助项目（81274088）