目的 观察降压中药济脉通片对长期饮酒大鼠的血压、肝肾功能及血管活性物质的影响。方法 SD大鼠40只，随机分为对照组、模型组、济脉通片组、氨氯地平组，每组10只，雌雄各半。大鼠自由饮用白酒，乙醇体积分数梯度递增，造模4周后开始ig给药，每天1次，连续给药49周。定期监测大鼠收缩压（SBP）、舒张压（DBP）、平均动脉压（MBP），检测血生化指标。末次给药后，大鼠下腔静脉丛取血，依次测血浆血管紧张素Ⅱ（Ang Ⅱ）、醛固酮（ALD）、血栓素B₂（TXB₂）水平。结果 连续饮酒12周，模型大鼠的血压（SBP、DBP、MBP）升高，直至饮酒53周仍稳定；济脉通片给药15周起，明显降低长期饮酒模型大鼠的血压（SBP、DBP、MBP），长达49周的给药期间显示其降压效果稳定（P<0.05、0.01）。济脉通片给药第38～48周，能不同程度降低饮酒模型大鼠血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）量（P<0.05、0.01）。济脉通片给药49周能够降低饮酒模型大鼠血浆ALD、Ang Ⅱ、TXB₂的量（P<0.05、0.01）。结论 济脉通片对长期饮酒致高血压模型大鼠有良好的降压作用，对大鼠肝损伤具有改善作用，其降压机制可能与肾素-血管紧张素-醛固酮系统、血栓素水平有关。

Objective To observe the effects of Jimaitong Tablet on the blood pressure, liver and kidney function, and vasoactive substances of the rats with long-term drinking. Methods Forty SD rats were divided into four groups including control, model, Jimaitong Tablet, and Amlodipine groups (n = 10). The rats drinking spirits freely, and the alcohol concentration increased in gradient. After 4 weeks of modeling, the rats were ig administered successively for 49 weeks, once daily. The blood pressure (such as SBP, DBP, and MBP) and blood biochemical markers of liver and kidney function (such as ALT, AST, Cr, and UA) had been regularly monitored. After the last administration, the rat blood was collected from the inferior vena cava plexus, and the angiotensin Ⅱ (Ang Ⅱ), aldosterone (ALD), and thromboxane B2 (TXB₂) levels in plasma were measured. Results The blood pressure (SBP, DBP, and MBP) of rats increased after 12-week continuous drinking and was stable until week 53. After the administration of Jimaitong Tablet for 15 weeks onwards, the blood pressure (SBP, DBP and MBP) of rats with long-term drinking could be significantly reduced. It showed stable antihypertensive effect during the administration for up to 49 weeks (P < 0.01, 0.05). Jimaitong Tablet could improve ALT and AST levels in serum to varying degrees (P < 0.01, 0.05) at the administration of 38—48 weeks. Jimaitong Tablet could reduce ALD, Ang Ⅱ, and TXB₂ levels (P < 0.01, 0.05) in plasma of the model rats during the administration of 49 weeks. Conclusion Jimaitong Tablet has good effect on hypertensive rats induced by long-term drinking, and has a distinct improving effect on liver injury in rats. Its mechanism of the antihypertensive effect may be related to the renin-angiotensin-aldosterone system and thromboxane level.

国家自然科学基金资助项目（81374003，81274123）；“重大新药创制”国家科技重大专项（2011ZX09101-002-07）；浙江省卫生高层次创新人才培养工程项目（浙卫发 [2010] 190号）