目的 拟制备pH依赖型黄芪多糖结肠定位释放喷雾干燥粉，以期达到结肠定位释药的目的。方法 以Eudragit S100水分散体为结肠靶向材料制备黄芪多糖结肠定位释放喷雾干燥粉，考察其体外释药性能，并对其进行扫描电镜（SEM）分析。结果 药物与Eudragit S100比例为1∶10时所制备的喷雾干燥粉在模拟人工胃液中基本不释药，在模拟人工肠液中，药物4 h的累积溶出率小于30.0%，在模拟人工结肠液中，1 h的体外累积溶出率达90.0%以上。结论 以Eudragit S100水分散体为载体制备的黄芪多糖结肠定位释放喷雾干燥粉达到了结肠定位释药的效果，其制备工艺简单、可行。

Objective To prepare the pH-dependent astragalus polvsaccharides colon-specific spray drying powder, with the intention of controlling drug release in the colon. Methods Eudragit S100 water dispersion was used as a carrier to prepare astragalus polvsaccharides colon-specific spray drying powder by spray drying method and the in vitro dissolution of spray drying powder was performed. The structure characteristics of spray drying powder was analyzed by SEM. Results When the ratio of drug to Eudragit S100 was 1:10, the drug in simulated gastric fluid did not release nearly and the accumulative drug-release percent in vitro at 4 h was less than 30.0%; But in the simulated colonic fluid, the accumulated drug release percent reached 90.0% within 1 h. Conclusion The astragalus polysaccharides colon-specific spray drying powder had the characteristics as a colon-specific delivery system. The preparation process is simple and feasible.

国家自然科学基金资助项目（81202929）