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[摘要]
目的 研究新疆芍药Paeonia sinjiangensis干燥根茎的化学成分。方法 采用硅胶、Sephadex LH-20、ODS柱色谱法及RP-HPLC进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果 从新疆芍药干燥根茎80%乙醇提取物中分离得到16个化合物,分别鉴定为8-去苯甲酰基芍药苷(1)、4-O-正丁基芍药苷(2)、没食子酰基芍药苷(3)、4-O-甲基苯甲酰基芍药苷(4)、苯甲酰基白芍苷(5)、白芍苷R1(6)、9-O-butylpaeonidanin(7)、(Z)-(1S, 5R)-β-pinen-10-yl β-vicianoside(8)、没食子酸(9)、没食子酸甲酯(10)、没食子酸乙酯(11)、异香草酸(12)、6-羟基香豆素(13)、3, 4, 23-trihydroxy-24, 30-dinorolean-12, 20(29)-dien-28-oic acid(14)、palbinone(15)、cadina-4, 11-dien-14-oic acid(16)。结论 化合物16为首次从毛茛科中分离得到,化合物1~15为首次从该植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents from the rhizomes of Paeonia sinjiangensis. Methods The chemical constituents were isolated and identified by chromatography on silica gel, Sephadex LH-20, ODS, and RP-HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analyses. Results Sixteen compounds were isolated from the 80% ethanol extract from the rhizomes of P. sinjiangensis, and identified as 8-debenzoylpaeoniflorin (1), 4-O-butylpaeoniflorin (2), galloylpaeoniflorin (3), 4-O-methylbenzoylpaeoniflorin (4), benzoylalbiflorin (5), albiflorin R1 (6), 9-O-butylpaeonidanin (7), (Z)-(1S, 5R)-β-pinen-10-yl β-vicianoside (8), gallic acid (9), methyl gallate (10), ethyl gallate (11), isovanillic (12), 6-hydroxycoumarin (13), 3, 4, 23-trihydroxy-24, 30-dinorolean-12, 20 (29)-dien-28-oic acid (14), palbinone (15), and cadina-4, 11-dien-14-oic acid (16). Conclusion Compound 16 is firstly isolated from the Ranunculaceae family, and compounds 1—15 are isolated from this plant for the first time.
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