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[摘要]
目的 研究向日葵Helianthus annuus 种子的化学成分。方法 利用反复硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化,通过NMR、MS等技术鉴定化合物结构。结果 从向日葵种子甲醇提取部位中分离得到16个化合物,分别鉴定为3, 4-二甲氧基-肉桂酸(1)、3-羟基-1-(4-羟基-3-甲氧基苯)-1-丙酮(2)、3-羟乙酰基吲哚(3)、7-羟基-6-乙酰基-2, 3-二甲氧基色酮(4)、泽兰内酯(5)、对羟基苯甲酸(6)、香草酸(7)、阿魏酸(8)、反式咖啡酸(9)、香豆酸(10)、烟酸(11)、3-吲哚甲醛(12)、3-吲哚甲酸(13)、豆甾醇(14)、β-谷甾醇(15)、β-胡萝卜苷(16)。结论 化合物1~3为首次从向日葵属植物中分离得到,化合物4为首次从本植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents from the seeds of Helianthus annuus. Methods The chemical constituents were isolated by repeated silica gel chromatography, Sephadex LH-20 gel column chromatography, medium pressure column chromatography, and semi-preparative liquid chromatography, and their structures were elucidated by chemical properties and spectroscopic analyses. Results Sixteen compounds were identified as 3, 4-dimethoxycinnamic acid (1), 3-hydroxy-1-(4-hydroxy-3- methoxy-phenyl)-1-propanone (2), 3-(hydroxyl-acetyl)-1H-indole (3), 6-acetyl-7-hydroxy-2, 3-dimethylchromone (4), ayapin (5), p-hydroxybenzoic acid (6), vanillic acid (7), ferulic acid (8), trans-caffeic acid (9), courmaric acid (10), nicotinic acid (11), indole-3-carboxaldehyde (12), indole-3-carboxylic acid (13), stigmasterol (14), β-sitosterol (15), and β-daucosterol (16). Conclusion Compounds 1—3 are obtained from genus Helianthus L. for the first time, and compound 4 is obtained from this plant for the first time.
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