[关键词]
[摘要]
目的 研究小果蔷薇Rosa cymosa根中的三萜类化学成分。方法 采用多种色谱柱对小果蔷薇中的化学成分进行分离纯化,并根据理化性质及波谱数据进行结构鉴定。结果 从小果蔷薇根醋酸乙酯部位中分离得到13个三萜类化合物,分别鉴定为2-oxo-pomolic acid(1)、2α, 19α-dihydroxy-3-oxo-12-ursen-28-oic acid(2)、2-乙酰基-洋委陵菜酸(3)、坡模酸(4)、野鸦椿酸(5)、阿江榄仁尼酸(6)、千花木酸(7)、阿江榄仁亭(8)、野蔷薇亭(9)、构莓苷F1(10)、2α, 3α, 19α, 23-四羟基乌苏-12-烯-28-羧酸-β-D-葡萄糖苷(11)、覆盆子酸(12)、号角树酸3-甲酯(13)。结论 化合物1~4、7、11~13为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the triterpenoid components of Rosa cymosa. Methods Compounds were isolated by repeated chromatography on silica gel column. The structures were elucidated by chemical and spectroscopic methods. Results Thirteen triterpenoids were isolated and identified as 2-oxo-pomolic acid (1), 2α, 19α-dihydroxy-3-oxo-12-ursen-28-oic acid (2), 2-acetyl tormentic acid (3), pomolic acid (4), euscaphic acid (5), arjunic acid (6), myrianthic acid (7), arjunetin (8), rosamultin (9), kaji-ichigoside F1 (10), 2α, 3α, 19α, 23-tetrahydroxy-12-ursen-28-O-β-D-glucoside (11), fupenzic acid (12), and cecropiacic acid 3-methyl ester (13). Conclusion Compounds 1—4, 7, and 11—13 are obtained from this plant for the first time.
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[基金项目]
国家自然科学基金资助项目(81360683);“十二五”“重大新药创制”创新药物研究开发技术平台建设,综合性新药研究开发技术大平台(2012ZX09301-002-001)