目的 建立保健品中非法添加13种减肥类化学成分的UPLC-MS/MS检测方法。方法 以甲醇超声提取样品，UPLC法进行色谱分析，采用串联四级杆质谱多反应监测（MRM）模式进行定性定量检测。结果 建立了快速检测保健品中13种减肥化学成分的方法，检测限低于2 ng。结论 本方法专属性强，灵敏度高，操作简单，快捷，可作为减肥类保健品中非法添加化学成分的有效检测方法。

Objective To develop a UPLC-MS/MS method for determination of the illegal addition of 13 components in slimming products. Methods Samples were extracted with methanol by ultrasonic processing, separated by quick UPLC, and detected by quadrupole mass spectrometry with “MRM” mode. Results The method for the rapid determination of the 13 components illegally added in slimming products was established, and the determination limits of quantification was below 2 ng. Conclusion The method is specific, sensitive, simple, and fast for the rapid determination of the components illegally added in slimming products.