目的 优选密闭性中药海绵敷料的最佳成型工艺。方法 采用正交设计法，以海绵的吸水率、保湿性、透气率为评价指标，对海绵的基质配比、加药浓度、交联剂用量进行优选研究。结果 密闭性中药海绵敷料的最佳成型工艺：海绵基质配比为聚乙烯醇-壳聚糖-明胶1∶3∶1；中药复方提取液浓缩为15∶3；交联剂戊二醛用量为0.7 mL。结论 海绵敷料的成型工艺稳定、切实可行，为产品后期产业化发展提供依据。

Objective To optimize the forming procedure of airtight Chinese medicine sponge dressings. Methods The forming procedure was investigated by orthogonal design, and the matrix ratio, drug concentration, and glutaraldehyde dosage were studied with water absorption, moisture, and permeability as evaluation indexes. Results The optimal forming procedure was as follows: the matrix ratio of polyvinyl alcohol-chitosan-gelatin was 1∶3∶1, the extracting solution of Chinese medicine compound was concentrated to 15∶3, and the dosage of glutaraldehyde was 0.7 mL. Conclusion The established forming procedure is stable and practicable, and laying a solid foundation for future industrial development.

广东省教育部产学研结合项目（2011B090400578）；广州市白云区科技项目基金（2009-st-01）