[关键词]
[摘要]
目的 研究锦灯笼Phyysalis alkekengi var. francheti果实的化学成分。方法 采用硅胶、制备液相等色谱技术进行分离,通过NMR等波谱学方法确定化合物的结构。结果 从锦灯笼大孔吸附树脂50%乙醇洗脱组分中分离得到13个化合物,分别鉴定为 (3S, 6R)-3-异丙基-6-(2-甲基丙基)-2, 5-哌嗪二酮(1)、(3S, 6S)-3-异丁基-6-异丙基-2, 5-哌嗪二酮(2)、(3S, 6S)-3, 6-二-(2-甲基丙基)-2, 5-哌嗪二酮(3)、(3S, 6S)-3, 6-二异丙基-2, 5-哌嗪二酮(4)、(3S, 6R)-3-(2-甲基丙基)-6-苄基-2, 5-哌嗪二酮(5)、(3S, 6S)-3-异丁基-6-苄基-2, 5-哌嗪二酮(6)、(3S, 6S)-3-异丙基-6-对羟基苄基-2, 5-哌嗪二酮(7)、(3S, 6R)-3-异丙基-6-对羟基苄基-2, 5-哌嗪二酮(8)、(3S, 6R)-3-(2-甲基丙基)-6-对羟基苄基-2, 5-哌嗪二酮(9)、(3S, 6S)-3-异丁基-6-对羟基苄基-2, 5-哌嗪二酮(10)、(3S, 6S)-3-异丙基-6-苄基-2, 5-哌嗪二酮(11)、(3S, 6R)-3-异丁基-6-(2-甲基丙基)-2, 5-哌嗪二酮(12)、(3S, 6S)-3-苄基-6-对羟基苄基-2, 5-哌嗪二酮(13)。结论 化合物1~13均为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in the fruits of Physalis alkekengi var francheti. Methods The piperazine constituents were isolated and purified with repeated silica gel column chromatography and RP-preparative HPLC. Their structures were determined by NMR spectroscopy. Results Thirteen compounds were isolated and elucidated as (3S, 6R)-3-isopropyl-6-(2- methyl propyl)-2, 5-piperazine diketone (1), (3S, 6S)-3-isobutyl-6-isopropyl-2, 5-piperazine diketone (2), (3S, 6S)-3, 6-two(2-methyl propyl)-2, 5-piperazine diketone (3), (3S, 6S)-3, 6-di-isopropyl-2, 5-piperazine di-ketone (4), (3S, 6R)-3-(2-methyl propyl)-6-benzyl- 2, 5-piperazine diketone (5), (3S, 6S)-3-isobutyl-6-benzyl-2, 5-piperazine diketone (6), (3S, 6S)-3-isopropyl-6-(p-hydroxy benzyl)-2, 5-piperazine diketone (7), (3S, 6R)-3-isopropyl-6-(p-hydroxy benzyl)-2, 5-piperazine diketone (8), (3S, 6R)-3-(2-methyl propyl)-6- (p-hydroxy benzyl)-2, 5-piperazine diketone 9), (3S, 6S)-3-isobutyl-6-(p-hydroxy benzyl)-2, 5-piperazine diketone (10), (3S, 6S)-3- isopropyl-6-benzyl-2, 5-piperazine diketone (11), (3S, 6R)-3-isobutyl-6-(2-methyl propyl)-2, 5-piperazine diketone (12), and (3S, 6S)-3-benzyl-6-(p-hydroxy benzyl)-2, 5-piperazine diketone (13). Conclusion Compounds 1—13 are firstly obtained from this plant.
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[基金项目]
国家重点基础研究发展计划(2013CB531800)