目的 研究车前子Plantaginis Semen不同炮制品的止泻作用；优化车前子炒制工艺。方法 采用醇水双提法提取车前子不同炮制品的有效成分，以腹泻指数为指标，观察不同炮制品对蓖麻油所致小鼠腹泻模型的影响；以京尼平苷酸、毛蕊花糖苷、水浸出物、醇浸出物的量为评价指标，采用星点设计-效应面优化法（CCD-RSM）优选车前子最佳炒制工艺参数。结果 车前子炒品、酒品和盐品对小鼠腹泻具有一定抑制作用，抑制作用强弱顺序为炒品＞酒品≥盐品，而生品有进一步加重小鼠腹泻的趋势；车前子最佳炒制工艺条件为取车前子饮片，210 ℃炒制5 min。结论 车前子不同炮制品的止泻作用存在差异；CCD-RSM科学性强、预测性好，所得的车前子最佳炒制工艺合理可行。

Objective To study the antidiarrheal effects of different processed products of Plantaginis Semen and to optimize the processing technology. Methods Alcohol and water were used as extracting agents of different processed products, diarrhea index was used as the index, and the antidiarrheal effects of different processed products on diarrheal mouse model induced by castor oil were observed. Taking the contents of geniposidic acid, acteoside, water extract, and alcohol extract as indexes, the stir-frying time and temperature of the processed products were optimized using star design-response surface optimization method (CCD-RSM). Results The fried-, wine-, and salt-processed products of Plantaginis Semen have certain inhibitory effect on the diarrhea of mice. The order of different processed products that restrain diarrhea respectively was: stir-fried product > stir-fried with yellow alcohol products ≥ stir-fried with salt, but the raw product could increase diarrhea of mice; The best processing technology was as follows: taking some Plantaginis Semen, fried for 5 min at 210 ℃. Conclusion There are differences in antidiarrheal effects of different processed products of Plantaginis Semen; CCD-RSM is scientific and predictable, and this process is rational and feasible.

基金项目：泸州医学院青年基金（427）