[关键词]
[摘要]
目的 研究云南土沉香Excoecaria acerifolia茎中的香豆素类化学成分。方法 采用正、反相硅胶柱色谱与Sephadex LH-20凝胶柱色谱进行分离纯化,并运用各种波谱方法鉴定化合物的结构。结果 从云南土沉香茎95%乙醇提取物中分离得到了12个香豆素类成分,分别鉴定为秦皮素8-O-β-D-葡萄糖苷(1)、秦皮素(2)、异秦皮素(3)、6-羟基-8-甲氧基-香豆素(4)、5, 7-二甲氧基-6-(1′, 2′, 3′-三羟基丙基)-2H-1-苯并吡喃-2-酮(5)、5′-二甲基沉香木质素(6)、瑞香辛(7)、臭矢菜素A(8)、臭矢菜素B(9)、白背叶素A(10)、白背叶素B(11)和白背叶素C(12)。结论 除化合物3和12外其他成分均为首次从海漆属植物中分离得到。
[Key word]
[Abstract]
Objective To study the coumarins from the stems of Excoecaria acerifolia. Methods The constituents were separated by column chromatography, and their structures were elucidated by spectral data analyses. Results Twelve coumarins were isolated from the EtOAc extract in stems of E. acerifolia and were identified as fraxidin 8-O-β-D-glucoside (1), fraxidin (2), isofraxidin (3), 6-hydroxy-8-methoxy-coumarin (4), 5,7-dimethoxy-6-(1′, 2′, 3′-trihydroxypropyl)-2H-1-benzopyran-2-one (5), 5′-demethylaquillochin (6), daphnecin (7), cleomiscosin A (8), cleomiscosin B (9), malloapelin A (10), malloapelin B (11), and malloapelin C (12). Conclusion All the compounds except 3 and 12 are obtained from the plants of Excoecaria Linn. for the first time.
[中图分类号]
[基金项目]
基金项目:国家自然科学基金青年基金资助项目(31300294);中央级公益性科研院所基本科研业务费海南省重大科技项目(ZDZX2013008-4,ZDZX2013023-1);公益性行业(农业)科研专项(201303117);国家科技支撑计划课题(2013BAI11B04)