[关键词]
[摘要]
目的 研究白钩藤Uncaria sessilifructus带钩茎枝的化学成分。方法 采用硅胶、MCI、Sephadex LH-20等柱色谱方法分离纯化,根据理化性质及波谱数据鉴定化合物结构。结果 从白钩藤干燥带钩茎枝95%乙醇提取物中分离得到了14个非生物碱类化合物:木栓酮(1)、桦木醇(2)、钝鸡蛋花素(3)、豆甾-4-烯-3-酮(4)、β-谷甾醇(5)、β-胡萝卜苷(6)、24-烯-环阿尔廷酮(7)、角鲨烯(8)、维生素E(9)、α-tocopherolquinone(10)、(?)-alloaromadendrene(11)、丁香色酮(12)、东莨菪内酯(13)、bis (2-ethylhexyl) phthalate(14);3个吲哚生物碱类化合物:大叶帽柱木碱(15)、异大叶帽柱木碱(16)、isomitraphylline N-oxide(17)。结论 化合物1、4、8、11、13为首次从钩藤属植物中分离得到,所有化合物均为首次从白钩藤中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the stems with hooks of Uncaria sessilifructus. Methods The chemical constituents were isolated and purified by chromatography on silica gel, MCI, Sephadex LH-20 columns, etc. The structures of compounds were elucidated by spectral analyses. Results Fourteen non-alkaloids compounds were isolated from the 95% ethanol extract from the stems with hooks of U. sessilifructus, and the structures were identified as friedelin (1), betulin (2), obtusalin (3), stigmast-4-en-3-one (4), β-sitosterol (5), β-daucosterol (6), 24-en-cycloartenone (7), squalene (8), vitamin E (9), α-tocopherolquinone (10), (?)-alloaromadendrene (11), eugenin (12), scopoletin (13), and bis (2-ethylhexyl) phthalate (14); Three alkaloids were identified as mitraphylline (15), isomitraphylline (16), and isomitraphylline N-oxide (17). Conclusion compounds 1, 4, 8, 11, and 13 are obtained from the plants of genus Uncaria Schreber nom. cons. for the first time, and all the above compounds are obtained from the stems with hooks of U. sessilifructus for the first time.
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[基金项目]
国家中医药管理局中医药重点学科建设项目(20270101805/002)