熊 吟,肖小河,鄢 丹,王伽伯,闫永红.综合量化集成的中药品质评控策略:中药效应成分指数[J].中草药,2014,45(1):1-7
综合量化集成的中药品质评控策略:中药效应成分指数
An integrated method for quality control of Chinese materia medica based on effect-constituent index
  
DOI:
中文关键词:  中药  品质评控  效应成分指数  化学成分分析  生物效应
英文关键词:Chinese materia medica  quality control  effect-constituent index  analysis of chemical constituents  bioeffect
基金项目:国家自然科学基金资助项目:“道地指数”的构建及其在中药材品质评控中的应用研究(81274026);国家留学基金
作者单位
熊 吟1, 2,肖小河1, 2,鄢 丹1,王伽伯1,闫永红2 1.解放军302医院 全军中药研究所北京 100039 2.北京中医药大学中药学院北京 100102 
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中文摘要:
      如何建立一套既能关联临床功效和安全性,又客观可靠、简便可行的中药品质评控方法和标准,对中药现代化发展具有重要的现实意义。为此,根据中药质量评控的基本现状和主要问题,将在构建化学成分分析与生物效应关联检测的基础上,尝试构建一套中药品质综合量化集成的评控新方法——中药效应成分指数(effect-constituent index,ECI),并结合实例分析对其研究思路进行阐释,以期使中药质量标准更好地助力于中药发展并服务临床。
英文摘要:
      It is of significance for the modernization of Chinese materia medica (CMM) to establish a set of quality control (QC) standards which could be related to the clinical efficacy and safety as well as reliable and easy to execute. According to the current situation and major problems of the QC for CMM, we first propose a comprehensive evaluating index—effect-constituent index (ECI) based on the chemical analysis and bioeffect detection. By instance analysis, the research approach about ECI was elucidated. We hope the establishment of ECI could provide the significant references to the QC of CMM and serve in clinic better.
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