[关键词]
[摘要]
目的 研究天麻Gastrodia elata的化学成分。方法 采用制备薄层色谱、硅胶柱色谱、Sephadex LH-20柱色谱、ODS柱色谱等方法进行分离纯化,根据理化性质及光谱数据鉴定化合物的结构。结果 从天麻50%乙醇提取物中分离得到了11个化合物,分别鉴定为天麻素(1)、对羟基苯甲醇(2)、对羟基苯甲酸(3)、对羟基苯甲醛(4)、对羟苄基甲醚(5)、巴利森苷(6)、4-(甲基亚磺酰甲基) 苯酚(7)、邻苯二甲酸二丁酯(8)、邻苯二甲酸二辛酯(9)、4, 4′-二羟基二苯基甲烷(10)、克罗酰胺(11)。结论 化合物7为新天然产物,化合物9和11为首次从兰科植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Gastrodia elata. Methods The constituents were isolated by various chromatographies, including preparative TLC, silica gel, Sephadex LH-20, and ODS columns, and their structures were elucidated on the basis of their physicochemical properties and spectral data. Results Eleven compounds were isolated from 70% EtOH fraction eluted from resin column and their structures were identified as gastrodin (1), 4-hydroxybenzyl alcohol (2), 4-hydroxybenzoic acid (3), 4-hydroxybenzaldehyde (4), 4-hydroxybenz-yl methyl ether (5), parishin (6), 4-(methylsulfinylmethyl) phenol (7), dibutyl phthalate (8), dioctyl phthalate (9), 4, 4′-dihydroxydiphenyl methane (10), and grossamide (11). Conclusion Compound 7 is a new natural product, and compounds 9 and 11 are isolated from the plants of Orchidacee for the first time.
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[基金项目]
国家科技支撑计划(2011BAI13B04);贵州省重大专项(黔科合重大专项字[2011]6005);江西省科技支撑计划项目(20121BBG70019);江西省卫生厅中医药科研计划(2012A019);江西中医药大学校级课题(2012ZR002)