目的 研究洋金花Datura metel 叶的化学成分。方法 应用乙醇提取洋金花叶，采用硅胶、AB-8大孔吸附树脂、ODS和Sephadex LH-20等柱色谱以及制备液相等技术分离纯化化合物，根据理化性质及波谱数据进行结构鉴定。结果 从洋金花叶中分离得到14个化合物，分别鉴定为naphthisoxazol A（1）、刺龙芽糖苷I（2）、L-色氨酸（3）、槲皮素3-O-2-(E-咖啡酸)-α-L-阿拉伯糖-(1→2)-β-D-吡喃葡萄糖-7-O-β-D-葡萄糖苷（4）、正丁基-O-α-D-呋喃果糖苷（5）、金线莲碱（6）、二氢催吐萝芙木醇-O-β-D-葡萄糖苷（7）、(6S, 7E, 9S)-9-[(β-D-glucopyranosyl)-oxy] megastigma-4, 7-dien-3-one（8）、山柰酚-3, 7-二- O-β-D-吡喃葡萄糖苷（9）、山柰酚-7-O-β-D-葡萄糖苷（10）、槲皮素-7-O-葡萄糖苷（11）、(6S, 9R)-6-羟基-3-酮-α-紫罗兰醇-9-O-β-D-葡萄吡喃糖苷（12）、豆甾醇（13）、豆甾醇-3-O-β-D-葡萄糖苷（14）。结论 化合物1～8为首次从茄科中分离得到。

Objective To study the chemical constituents in the leaves of Datura metel. Methods The chemical constituents of ethanol extract from the leaves of D. metel were isolated and purified by chromatography over silica gel, AB-8 macroperous resin, ODS, Sephadex LH-20 columns, and RP-preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral data analyses. Results Forteen compounds were isolated and identified as naphthisoxazol A (1), congmuyaglyeoside I (2), L-tryptophan (3), quercetin3-O-2-(E-caffeoyl)-α-larabinopyranosyl-(1→2)-β-D-glucopyranoside-7-O-β-D-glucoside (4), n-butyl- O-α-D-fructofuranosidase (5), anoectochine (6), dihydrovomifoliol-O-β-D-glucoside (7), (6S, 7E, 9S)-9-[(β-D-glucopyranosyl)-oxy] megastigma-4, 7-dien-3-one (8), kaepmferol-3, 7-di-O-β-D-glucopyranoside (9), kaempferol-7-O-β-D-glucoside (10), quercetin-7- O-glucoside (11), (6S, 9R)-6-hydroxy-3-ketone-α-violet-grape alcohol-9-O-β-D-glucopyranoside (12), stigmasterol (13), and stigmasterol-3-O-β-D-glucoside (14). Conclusion Compounds 1—8 are firstly found in the plants of Solanaceae.