[关键词]
[摘要]
目的 研究毛木防己Cocculus orbiculatus var. mollis根中的生物碱类化学成分。方法 利用硅胶柱色谱及重结晶方法分离纯化,通过化学及波谱分析方法鉴定化合物的结构。结果 从毛木防己根95%乙醇提取物中分离并鉴定了1个较少见的C-α羟基取代的新BBI生物碱木防己亭碱(1)及3个已知生物碱,分别为去氢艾帕特啉碱(2)、木防己碱(3)、异木防己碱(4)。结论 化合物1为新化合物,命名为木防己亭碱,化合物2~4为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the alkaloid compounds in the roots of Cocculus orbiculatus var. mollis. Methods The compounds were isolated by silica gel chromatography, and their structures were established by spectroscopic methods. Results A novel cocsolines-type bisbenzylisoquinoline alkaloid named orbiculatinine (1), along with three known compounds (+) 1, 2- dehydroapateline (2), trilobine (3), and isotrilobine (4), were isolated. Conclusion Compound 1 is a new compound named orbiculatinine. Compounds 2-4 are isolated from this plant for the first time.
[中图分类号]
[基金项目]