[关键词]
[摘要]
目的 制备姜黄素温敏型纳米凝胶,并考察其体外释药性能。方法 采用乳液聚合法,制备了聚N-异丙基丙烯酰胺(PNIPAm)温敏型纳米凝胶,并以其为载体,包载姜黄素,对载体性质、载药量、释放度进行考察。结果 原子力显微镜法(AFM)观察制备的PNIPAm纳米凝胶,球形完整,粒径分布均匀;PNIPAm纳米凝胶(No. 5)载药量达27%,24 h体外累积释药量为75.2%。结论 所得姜黄素PNIPAm温敏型纳米凝胶制备方法简便,有望成为姜黄素的新型纳米给药系统。
[Key word]
[Abstract]
Objective To prepare curcumim thermoresponsive nanogels and study its release characteristics in vitro. Methods Poly (N-isopropyl acrylamide) (PNIPAm) thermoresponsive nanogels were synthesized by emulsion polymerization method, and then curcumin loaded-PNIPAm nanogels were prepared. The characteristics of PNIPAm nanogels, the drug loading, and the drug release in vitro were investigated. Results Atomic force micriscopy (AFM) observation showed that PNIPAm nanogels were spherical in shape with homogenous size. Moreover, PNIPAm No. 5 showed a high drug loading (27%). In vitro release study revealed that the 24 h accumulative in vitro release reached 75.2%. Conclusion The method used to prepare curcumin thermoresponsive nanogels is simple. It is expected to become a novel vehicle potentially nanoparticle drug delivery system of curcumin.
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[基金项目]
国家自然科学基金资助项目(81173006,81273469);天然药物活性组分与药效国家重点实验室资助项目(JKGQ201107);2012年度江苏省高校“青蓝工程”项目