[关键词]
[摘要]
目的 研究壮药桫椤Alsophila spinulosa茎的化学成分。方法 采用硅胶、聚酰胺、Sephadex LH-20柱色谱等方法进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果 从龙骨风95%乙醇和50%乙醇提取物中分离得到16个化合物,分别鉴定为东北贯众醇-30-O-β-D-吡喃木糖苷(1)、海松酸(2)、9α-羟基-1β-甲氧基石竹烷醇(3)、6β-羟基-24-乙基-胆甾-4-烯-3-酮(4)、十六烷酸甘油酯(5)、丁香烷二醇(6)、decumbic acid(7)、正二十四烷(8)、对香豆酸-4-O-β-D-吡喃葡萄糖苷(9)、反式咖啡酸-4-O-β-D-吡喃葡萄糖苷(10)、桫椤诺生A(11)、原儿茶醛(12)、原儿茶酸(13)、豆甾烷-3, 6-二酮(14)、β-谷甾醇(15)和胡萝卜苷(16)。结论 化合物1为新化合物,命名为龙骨风新苷A,化合物2~11均为首次从该植物中分离得到。
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[Abstract]
Objective To study the chemical constituents in the stems of Zhuang Medicine Alsophila spinulosa. Methods The chemical constituents were isolated and purified by silica gel, polyamide, and Sephadex LH-20 column chromatography. Their structures were elucidated by physicochemical properties and spectral analyses. Results Sixteen compounds were isolated from the 50% and 95% ethanol extracts and identified as 30-O-β-D-xylopyranosyl-dryocrassol (1), pimaric acid (2), 9α-hydroxy-1β- methoxycaryolanol (3), 6β-hydroxy-24-ethyl-cholest-4-en-3-one (4), 1-O-hexadecanolenin (5), clovandiol (6), decumbic acid (7), n-tetracosane (8), 4-O-β-D-glucopyranosyl-p-coumaric acid (9), (E)-4-O-β-D-glucopyranosyl caffeic acid (10), cyathenosin A (11), protocatechualdehyde (12), protocatechuic acid (13), stigmastane-3, 6-dione (14), β-sitosterol (15), and daucosterol (16). Conclusion Compound 1 is a new compound named alspineoside A, and compounds 2-11 are isolated from the stems of A. spinulosa for the first time.
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[基金项目]
广西高校优秀人才资助计划项目(J10002)