[关键词]
[摘要]
目的 对紫花前胡Peucedanum decursivum的化学成分进行研究。方法 采用95%乙醇提取,经多种色谱方法分离纯化,利用质谱、核磁共振等现代波谱技术鉴定结构。结果 从紫花前胡95%乙醇提取物的醋酸乙酯萃取物中分离得到12个化合物,分别鉴定为异佛手柑内酯(1)、佛手柑内酯(2)、茴芹内酯(3)、异茴芹内酯(4)、二氢欧山芹醇乙酯(5)、6-牛防风素(6)、前胡香豆素E(7)、花椒毒素(8)、甲氧基欧芹酚(9)、阿魏酸(10)、β-谷甾醇(11)、补骨脂素(12)。结论 化合物1、4、5为首次从前胡属植物中分离得到,化合物2、3、6~10、12为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from Peucedanum decursivum. Methods P. decursivum was extracted with 95% ethanol, the compounds were isolated via various chromatographic methods, and their structures were identified by detailed spectroscopic analyses. Results Twelve compounds were isolated from the acetic ether fraction in the 95% extract of P. decursivum and were identified as isobergapten (1), bergapten (2), pimpinellin (3), isopimpinellin (4), columbianetin acetate (5), sphondin (6), qianhucoumarin E (7), xanthotoxin (8), osthole (9), ferulic acid (10), β-sitosterol (11), and psoralen (12). Conclusion Compounds 1, 4, and 5 are isolated from the plants in Peucedanum L. for the first time, and compounds 2, 3, 6-10, and 12 are firstly isolated from P. decursivum.
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[基金项目]
2010年国家生物医药国际创新园专项(10ZCKFSY08800);2011年科技型中小企业创新基金项目(国家11C26211203971,天津市11ZXCXSY03500)