[关键词]
[摘要]
目的 研究多棘蜈蚣Scolopendra multidens的化学成分。方法 采用硅胶柱色谱、反相柱色谱、Sephadex LH-20柱色谱、中低压制备色谱、制备HPLC等方法进行分离纯化,并根据理化性质和波谱数据鉴定化合物结构。结果 从多棘蜈蚣乙醇冷浸提取物中分离得到了10个化合物,分别鉴定为尿嘧啶(1)、7, 8-二甲基异咯嗪(2)、吲哚-3-乙酰胺(3)、N-乙酰基-2-苯基乙胺(4)、(3S)-1, 2, 3, 4-四氢-β-咔啉-3-羧酸(5)、环 (L-异亮-L-脯) 二肽(6)、环 (L-亮-L-脯) 二肽(7)、环 (L-苯丙-L-脯) 二肽(8)、环 (L-苯丙-L-酪) 二肽(9)、环 (L-缬-L-脯) 二肽(10)。结论 所有化合物均为首次从多棘蜈蚣中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Scolopendra multidens. Methods Compounds were isolated and purified by a combination of chromatographic techniques including silica gel, ODS, Sephadex LH-20 column chromatography, middle and low pressure preparative chromatograms, and pre-HPLC. The structures were elucidated on the basis of physicochemical properties and spectroscopic analyses. Results Ten compounds were separated and identified as uracil (1), 7, 8- dimethyl-isoalloxazine (2), indole-3-acetamide (3), N-(2-phenylethyl) acetamide (4), (3S)-1, 2, 3, 4-tetrahydro-β-carboline-3- carboxylic acid (5), cyclo-(L-Ile-L-Pro) (6), cyclo-(L-Leu-L-Pro) (7), cyclo-(L-Phe-L-Pro) (8), cyclo-(L-Phe-L-Tyr) (9), and cyclo-(L-Val-L-Pro) (10). Conclusion All the compounds are isolated from S. multidens for the first time.
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[基金项目]
江苏省重大科技项目(BM2010610)