[关键词]
[摘要]
目的 对苍耳子Xanthii Fructus的化学成分进行研究。方法 利用正相硅胶柱色谱、反相ODS柱色谱、Sephadex LH-20柱色谱、重结晶等方法进行分离和纯化,根据理化性质和波谱数据进行结构鉴定。结果 从苍耳子的95%乙醇提取物中分离得到了15个化合物,分别鉴定为百合内酯(1)、(3S, 5R, 6S, 7E)-5, 6-epoxy-3-hydroxy-7-megastigmene-9-one(2)、7α-羟基-β-谷甾醇(3)、豆甾-4-烯-3β, 6α-二醇(4)、6′-棕榈酰基-β-胡萝卜苷(5)、β-谷甾醇(6)、β-胡萝卜苷(7)、蛇菰宁(8)、松脂醇(9)、苍耳亭(10)、苍耳皂素(11)、苍耳烯吡喃(12)、对羟基苯甲醛(13)、3-羟基-4-甲氧基反式桂皮醛(14)、槲皮素(15)。结论 化合物1~5为首次从苍耳属植物中分离得到,化合物8为首次从苍耳中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Xanthii Fructus. Methods The compounds were isolated and purified by chromatography on silica gel, ODS, and Sephadex LH-20 columns, and their structures were determined according to physicochemical properties and spectral analyses. Results Fifteen compounds were obtained and identified as loliolide (1), (3S, 5R, 6S, 7E)-5, 6-epoxy-3-hydroxy-7-megastigmene-9-one (2), 7α-hydroxy-β-sitosterol (stigmast-5-ene-3β, 7α-diol) (3), stigmast-4-ene- 3β, 6α-diol (4), 6′-palmitoxyl-β-daucosterin (5), β-sitosterol (6), daucosterol (7), balanophonin (8), pinoresinol (9), xanthatin (10), xanthinosin (11), xanthienopyran (12), p-hydroxybenzaldehyde (13), 3-methoxy-4-hydroxy-transcinnamaldehyde (14), and quercetin (15). Conclusion Compounds 1—5 are obtained from the plants in Xanthium L. for the first time, and compound 8 is isolated from this plant for the first time.
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[基金项目]
中国科学院重要方向性项目(KSCX2-EW-R-15)