目的 研究小桃儿七Helleborus thibetanus的化学成分。方法 运用硅胶柱色谱及重结晶等方法进行分离纯化，根据理化性质和核磁共振波谱对化合物进行结构鉴定。结果 从小桃儿七乙醇提取物中分离得到1个新化合物，鉴定为14β-羟基-3β-[(β-D-葡萄吡喃糖基) 氧]-5α-蟾酥甾-20, 22-二烯（1）。结论 化合物1为新化合物，命名为铁筷子苷A，属于蟾蜍二烯羟酸内酯类强心苷类化合物。

Objective To study the chemical constituents in the ethanol extract from the roots and rhizomes of Helleborus thibetanus. Methods The compounds were isolated and purified by silica gel column chromatography and recrystallization. The structures of the compounds were identified on the basis of chemical and spectral methods. Results A new compound was isolated from the ethanol extract in the roots and rhizomes of H. thibetanus and identified as 14β-hydroxy-3β-[(β-D-glucopyranosyl)oxy]-5α-bufa-20, 22-dienolide (1). Conclusion Compound 1 is a new compound named as hellebocoside A, which belongs to bufadienolide of cardiac glycosides.

教育部新世纪优秀人才支持计划资助项目（NCET-09-0589）