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[摘要]
目的 分别对鸢尾属2种植物膜苞鸢尾Iri scariosa和蓝花喜盐鸢尾Iri halophila var. sogdiana的根及根状茎的化学成分进行研究。方法 利用正、反相硅胶柱色谱、凝胶柱色谱、大孔树脂柱色谱、反相制备色谱等技术进行分离纯化,根据波谱学数据(MS、1H-NMR、13C-NMR、2D-NMR)进行化合物的结构鉴定。结果 从膜苞鸢尾的根及根状茎中分离得到6个化合物,分别鉴定为野鸢尾苷元(1)、尼鸢尾黄素-4′-[O-β-D-吡喃葡萄糖基-(1′′′→6′′)-β-D-吡喃葡萄糖苷](2)、5, 7, 2′-三羟基-6-甲氧基二氢黄酮(3)、尼鸢尾黄素(4)、德鸢尾苷元(5)、鸢尾酚酮(6)。从蓝花喜盐鸢尾的根及根状茎中分离鉴定了7个化合物:5, 7, 2′-三羟基-6-甲氧基二氢黄酮(3)、5, 2′-二羟基-6, 7-二甲氧基异黄酮(鸢尾灵A,7)、鸢尾甲黄素B(8)、鸢尾甲黄素B 4′-O-β-D-吡喃葡萄糖苷(9)、鸢尾甲黄素B 4′-[O-β-D-吡喃葡萄糖基-(1′′′→6′′)-β-D-吡喃葡萄糖苷](10)、山姜酮(11)和β-胡萝卜苷(12)。结论 化合物9为新化合物,命名为喜盐鸢尾苷。化合物1~6是首次从膜苞鸢尾中分离得到,化合物3、7~12是首次从蓝花喜盐鸢尾中分离得到。
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[Abstract]
Objective To investigate the chemical constituents in the roots and rhizomes of Iris scariosa and Iris halophila var. sogdiana, respectively. Methods The chemical constituents were isolated and purified by column chromatography (silica gel, ODS, Sephadex LH-20, and macroporous resin HP-20) and RP-preparative TLC. Their structures were identified by spectroscopic methods (MS, 1H-NMR, 13C-NMR, and 2D-NMR). Results Six compounds, irigenin (1), nigricin-4′-[O-β-D-glucopyranosyl-(1′′′→6′′)-β- D-glucopyranoside] (2), 5, 7, 2′-trihydroxy-6-methoxy-flavanone (3), nigricin (4), irilone (5), and iriflophenone (6) were isolated and identified from the roots and rhizomes of I. scariosa. Besides, seven compounds, 5, 7, 2′-trihydroxy-6-methoxy-flavanone (3), irilin A (7), iristectorigenin B (8), iristectorigenin B 4′-O-β-D-glucopyranoside (9), iristectorigenin B 4′-[O-β-D-glucopyranosyl-(1′′′→6′′)- β-D-glucopyranoside (10), alpinone (11), and β-daucosterol (12) were isolated and identified from the roots and rhizomes of I. halophila var. sogdiana. Conclusion Compound 9 is a new one named halophiloside. Compounds 1—6 are isolated from I. scariosa and compounds 3 and 7—12 are isolated from I. halophila var. sogdiana for the first time, respectively.
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[基金项目]
重大新药创制专项(一种新型黄酮类阻止A-beta聚集的候选药物,2013ZX09103001-019-001)