[关键词]
[摘要]
目的 研究银杏Ginkgo biloba 根皮的化学成分。方法 采用多种柱色谱分离纯化,通过理化常数测定和波谱分析鉴定化合物结构。结果 从银杏根皮中分离得到13个化合物,其中脂肪酸类4个:棕榈酸(1)、硬脂酸(2)、山嵛酸(3)、木蜡酸(4);脂肪醇类1个:正二十七烷醇(5);甾体类2个:β-谷甾醇(6)、胡萝卜苷(7);黄酮类2个:芫花素(8)、芹菜素(9);萜内酯类4个:白果内酯(10)、银杏内酯A(11)、银杏内酯B(12)、银杏内酯C(13)。结论 化合物1~9为首次从银杏根皮中分离得到,其中化合物3~5为首次从该植物中分离得到,该研究为银杏根皮资源的综合利用奠定了基础。
[Key word]
[Abstract]
Objective To study the chemical constituents from the root barks of Ginkgo biloba. Methods The constituents were isolated by column chromatography and their structures were elucidated by physicochemical properties and spectroscopic analyses. Results Thirteen compounds were isolated including four fatty acids, palmitinic acid (1), stearic acid (2), behenic acid (3), and lignoceric acid (4); one fatty alcohol, 1-heptacosanol (5); two sterides, β-sitosterol (6) and daucosterol (7); two flavonoids, genkwanin (8) and apigenin (9); and four ginkgolides, bilobalide (10), ginkgolide A (11), ginkgolide B (12), and ginkgolide C (13). Conclusion Among them, compounds 3—5 are isolated from this plant for the first time. The results are helpful for the comprehensive utilization of the resources of the root barks of G. biloba.
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[基金项目]
国家科技支撑计划(2011BAI04B03);江苏省高校优势学科建设工程资助项目(ysxk-2010)