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[摘要]
目的 研究吴茱萸Euodia rutaecarpa干燥果实的化学成分。方法 采用硅胶、Sephadex LH-20等开放柱色谱及半制备HPLC等方法对吴茱萸乙醇提取物进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果 从吴茱萸95%乙醇提取物中分离得到11个化合物,分别鉴定为吴茱萸碱(evodiamine,1)、吴茱萸次碱(rutaecarpine,2)、3-(2′-羟基乙酰基)-吲哚(3-hydroxyacetylindole,3)、N-反式对羟基肉桂酰基-对羟基苯乙胺 [N-(trans-p-coumaroyl)-tyramine,4]、N-顺式对羟基肉桂酰基-对羟基苯乙胺 [N-(cis-p-coumaroyl)-tyramine,5]、白鲜碱(dictamnine,6)、吴茱萸春(evolitrine,7)、6-甲氧基白鲜碱(6-methoxydictamnine,8)、茵芋碱(skimmiamine,9)、7-羟基吴茱萸次碱(7-hydroxyrutaecarpine,10)、阿塔宁I(atanine I,11)。结论 化合物3为首次从该属植物中分离得到;化合物4~11为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the fruits of Euodia rutaecarpa. Methods The chemical constituents of ethanol extract from E. rutaecarpa were isolated and purified by chromatography over silica gel, Sephadex LH-20 columns, and semipreparative reversed-phase HPLC. The structures were elucidated on the basis of physicochemical properties and spectral data analyses. Results Eleven compounds were isolated and identified as evodiamine (1), rutaecarpine (2), 3-hydroxyacetylindole (3), N-(trans-p-coumaroyl)-tyramine (4), N-(cis-p-coumaroyl)-tyramine (5), dictamnine (6), evolitrine (7), 6-methoxydictamnine (8), skimmiamine (9), 7-hydroxyrutaecarpine (10), and atanine I (11). Conclusion Compound 3 is reported for the first time from the plants of genus Euodia J. R. et G. Forst. and compounds 4—11 are reported for the first time from E. rutaecarpa.
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[基金项目]
国家“十二五”计划重大新药创新专项(30873385,81274078)