目的 研究鸡骨香Croton crassifolius的化学成分。方法 通过萃取、硅胶柱色谱及重结晶等方法，对鸡骨香的乙醇提取物进行了分离纯化，并根据化合物的理化性质和波谱分析鉴定其结构。结果 从鸡骨香中分离鉴定了10个化合物，分别是cyperenoic acid（1）、β-谷甾醇（2）、羽扇豆醇（3）、chettaphanin II（4）、9-[2-(2(5H)-呋喃酮-4-)乙基]-4, 8, 9-三甲基- 1, 2, 3, 4, 5, 6, 7, 8-八氢萘环-1-羧酸（5）、acetyl aleuritolic acid（6）、epitaraxerol（7）、9-[2-(2(5H)-呋喃酮-4-)乙基]-4, 8, 9-三甲基-1, 2, 3, 4, 5, 6, 7, 8-八氢萘环-1-甲酯（8）、teucvidin（9）、豆甾醇（10）。结论 化合物5、8为新化合物，分别命名为鸡骨香酸和鸡骨香酯，化合物4、6、7为首次从该植物中分离得到。

Objective To investigate the chemical constituents of Croton crassifolius. Methods A number of methods, such as extraction, chromatography on silica gel, and recrystallization, were utilized to isolate and purify the ethanol extract from C. crassifolius, and the structures of the compounds isolated were identified by physicochemical properties and spectral analyses. Results Ten compounds were isolated and identified as cyperenoic acid (1), β-sitosterol (2), lupeol (3), chettaphanin II (4), 9-[2-(2(5H)- furanone-4-yl)ethyl]-4, 8, 9-trimethyl-1, 2, 3, 4, 5, 6, 7, 8-octahydro-naphthalene-4-carboxylic acid (5), acetyl aleuritolic acid (6), epitaraxerol (7), 9-[2-(2(5H)-furanone-4-yl)ethyl]-4, 8, 9-trimethyl-1, 2, 3, 4, 5, 6, 7, 8-octahydronaphthalene-4-carboxylic ester (8), teucvidin (9), and stigmasterol (10). Conclusion Compounds 5 and 8 are newly-discovered compounds, named as crassifolius acid and crassifolius ester, and compounds 4, 6, and 7 are isolated from this plant for the first time.

国家自然科学基金项目（21310104，20772047）；广东省自然科学基金项目（32210018）；广东省医学科学技术研究基金项目（A2011344）