目的 研究恒山黄芪粉碎度与黄芪多糖得率之间的关系。方法 采用超微粉碎机对恒山黄芪进行超细化处理并按不同粒度分组，比较各组别恒山黄芪在不同温度、不同料液比条件下，水法提取与CaO法提取黄芪多糖的得率。结果 恒山黄芪粉体粒度≥600目（破壁前），黄芪多糖得率同等粉碎度CaO法提取优于水法提取，小于800目（破壁后）得率趋于一致。无论是采用水法还是CaO法提取，恒山黄芪在粉碎粒度为800目时，选择提取温度80 ℃，料液比1∶8，黄芪多糖得率达到最高，分别为8.36%和8.49%。结论 恒山黄芪多糖得率与粉碎度存在关联性。

Objective To study the correlation between the comminution degree and astragalus polysaccharides yield in Mt. Hengshan Astragalus membranaceus (MHAM). Methods MHAM was processed with the ultrafine treatment by mini plant mill, and grouped according to the different sizes. The yields of astragalus polysaccharides in each group were obtained under the different temperatures and ratios of material to liquid by water and CaO extraction methods. Results When the powder size ≥ 600-mesh, the yield of astragalus polysaccharides with CaO extraction is higher than that with water extraction; When the powder size = 800-mesh, the yields are almost the same by the two extraction methods. With the methods of both water and CaO extraction, the highest yields of astragalus polysaccharides (8.36% and 8.49%) were obtained at the following conditions: 800-mesh crushing granularity, 80 ℃ extraction temperature, and 1:8 solid-liquid ratio. Conclusion The yield of astragalus polysaccharides and the comminution degree of MHAM are related.

山西省科技厅攻关课题（20080321074）；山西省教育厅科研课题（20091142）