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[摘要]
目的 研究毛酸浆Physalis pubescens浆果的化学成分。方法 利用反复硅胶柱色谱、Sephadex LH-20凝胶柱色谱、中压柱色谱及半制备高效液相色谱等方法分离纯化,根据核磁共振谱、质谱等谱学数据鉴定化合物结构。结果 从毛酸浆浆果中分离得到16个化合物,分别鉴定为3, 7, 3′-三甲基槲皮素(1)、山柰酚(2)、金圣草酚(3)、槲皮素-3-O-β-D-吡喃葡萄糖苷(4)、2α, 3β, 23-三羟基-12-烯-28-齐墩果酸(5)、白头翁皂苷A(6)、白头翁皂苷D(7)、咖啡酸(8)、1-O-咖啡酰基-β-D-吡喃葡萄糖(9)、N-反式-阿魏酰酪胺(10)、新橄榄脂素(11)、梣皮树脂醇(12)、松脂醇(13)、蔗糖(14)、尿苷(15)、β-谷甾醇(16)。结论 化合物5~7、9~15为首次从酸浆属植物中分离得到,化合物3、8为首次从该植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents from the berries of Physalis pubescens. Methods The chemical constituents were isolated by repeated silica gel column chromatography, Sephadex LH-20 gel columns chromatography, medium pressure column chromatography, and semi-preparative liquid chromatography, and their structures were elucidated by chemical properties and spectral analyses. Results Sixteen compounds were isolated and identified to be 3, 7, 3′-trimethylquercetin (1), kaempferol (2), chrysoeriol (3), quercetin-3-O-β-D-glucopyranoside (4), arjunolic acid (5), pulsatilla saponin A (6), pulsatilla saponin D (7), caffeic acid (8), 1-O-caffeoyl-β-D-glucopyranoside (9), N-trans-ferulogltyramine (10), neo-olivil (11), medioresinol (12), pinoresinol (13), sucrose (14), uridine (15), and β-sitosterol (16). Conclusion Compounds 5—7 and 9—15 are obtained from the plants of genus Physalis L. for the first time. Compounds 3 and 8 are obtained from this plant for the first time.
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