目的 优选复方止痛巴布剂最佳基质处方。方法 采用单因素试验、星点设计-效应面优化法，以初黏力和外观（膏体性状、残留性、皮肤追随性）为评价指标，对巴布剂基质处方进行优选，以确定最佳制备工艺。结果 优选基质配比为NP-700-卡波姆940-甘羟铝-微粉硅胶-甘油（5.34∶0.63∶0.2∶6∶30）。结论 优选所得基质黏着力适中，无残留，膏体性状、皮肤追随性均较好，制备工艺良好。

Objective To optimize the matrix recipe of Compound Analgesic Cataplasm. Methods Taking the early adhesion and appearance (paste traits, residue, and skin adhesive ability) as evaluation indexes, the optimal matrix recipe of Compound Analgesic Cataplasm was optimized by single factor test and central composite design-response surface method, and the optimal preparation process was determined at the same time. Results The optimal ratio of the matrix is as follows: NP-700-carbopol 940-aluminium glycinate-silica-glycerin (5.34∶0.63∶0.2∶6∶30). Conclusion The optimal matrix has the moderate adhesion without residue but with better paste traits and skin adhesive ability under the ideal preparation technology.

国家“973”项目释药机理与技术研究（2010CB735602）