[关键词]
[摘要]
目的 对丽江产紫乌头Aconitum episcopale中的二萜生物碱进行研究。方法 运用多种色谱技术进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果 从丽江紫乌头中分离得到了10个二萜生物碱,分别鉴定为塔拉萨敏(1)、查斯曼宁(2)、草乌甲素(3)、丽江乌头碱(4)、acoforestinine(5)、滇乌碱(6)、3-去氧-8-去乙酰基滇乌碱(7)、leucanthumsine D(8)、pengshenine B(9)、macrorhynine B(10)。结论 其中化合物2~5、7~10均为首次从该种植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the diterpenoid alkaloids from Aconitum episcopale. Methods The obtained compounds were isolated by different chromatographic methods and their structures were identified by physicochemical properties and spectral data. Results Ten diterpenoid alkaloids were isolated and identified as talatizamine (1), chasmanine (2), crassicauline A (3), foresaconitine (4), acoforestinine (5), yunaconitine (6), 3-deoxy-8-deacetyl-yunaeonitin (7), leucanthumsine D (8), pengshenine B (9), and macrorhynine B (10). Conclusion Compounds 2—5 and 7—10 are isolated from this plant for the first time.
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[基金项目]
国家重点基础研究发展计划(“973”计划)(2009CB522300);云南省自然科学基金项目(2010GA014)