[关键词]
[摘要]
目的 研究川西獐牙菜Swertia mussotii的化学成分。方法 采用柱色谱方法进行分离纯化,根据理化性质和波谱解析鉴定化合物结构。结果 从川西獐牙菜75%乙醇提取物中分离得到19个化合物,分别鉴定为1-羟基-3, 4, 7, 8-四甲氧基呫吨酮(1)、1, 7-二羟基-3-甲氧基呫吨酮(2)、1, 3, 7-三羟基呫吨酮(3)、1, 3, 7, 8-四羟基呫吨酮(4)、1, 3, 8-三羟基-7-甲氧基呫吨酮(5)、1, 3-二羟基-7, 8-二甲氧基呫吨酮(6)、1, 5, 8-三羟基-3, 4-二甲氧基呫吨酮(7)、1-羟基-3, 4, 5, 8-四甲氧基呫吨酮(8)、1-羟基-3, 5, 8-三甲氧基呫吨酮(9)、(S)-(+)-龙胆内酯(10a)、(R)-(?)-龙胆内酯(10b)、1, 8-二羟基-3, 7-二甲氧基呫吨酮(11)、1-羟基-3, 7, 8-三甲氧基呫吨酮(12)、1, 7-二羟基-3, 8-二甲氧基呫吨酮(13)、1, 7, 8-三羟基-3-甲氧基呫吨酮(14)、1, 3, 5, 8-四羟基呫吨酮(15)、1, 7-二羟基-3, 4, 8-三甲氧基呫吨酮(16),芒果苷(17)、齐墩果酸(18)。结论 化合物1~9 均为首次从该种植物中分离得到,化合物10a和10b为首次从獐牙菜属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Swertia mussotii. Methods Various chromatographic methods were employed to isolate the compounds and their structures were established by spectroscopic analysis. Results Nineteen compounds were isolated from 75% ethanol extract of S. mussotii and identified as 1-hydroxyl-3, 4, 7, 8-tetramethoxyxanthone (1), 1, 7- dihydroxyl-3-methoxyxanthone (2), 1, 3, 7-trihydroxyxanthone (3), 1, 3, 7, 8-tetrahydroxyxanthone (4), 1, 3, 8-trihydroxyl-7- methoxyxanthone (5), 1, 3-dihyfroxyl-7, 8-dimethoxyxanthone (6), 1, 5, 8-trihydroxyl-3, 4-dimethoxyxanthone (7), 1-hydroxyl-3, 4, 5, 8-tetramethoxyxanthone (8), 1-hydroxyl-3, 5, 8-trimethoxyxanthone (9), (S)-(+)-gentiolactone (10a), (R)-(?)-gentiolactone (10b), 1, 8-dihydroxyl-3, 7-dimethoxyxanthone (11), 1-hydroxyl-3, 7, 8-trimethoxyxanthone (12), 1, 7-dihydroxyl-3, 8-dimethoxyxanthone (13), 1, 7, 8-trihydroxyl-3-methoxyxanthone (14), 1, 3, 5, 8-tetrahydroxyxanthone (15), 1, 7-dihydroxyl-3, 4, 8-trimethoxyxanthone (16), mangiferin (17), and oleanolic acid (18), respectively. Conclusion Compounds 1—9 are firstly isolated from S. mussotii. Compounds 10a and 10b are firstly isolated from the plants in Swertia L.
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[基金项目]
国家自然科学基金资助项目(81172982);广东省科技计划项目(2010A030100006)