目的 优选不同辅料膏方制备工艺的最佳条件参数。方法 以膏方的性状特征、成膏率及药材检出情况为控制指标，采用多指标综合评分法评价膏方成型性；以辅料的使用量（A）、清膏（B）和成品膏（C）的相对密度为3个因素，采用星点设计进行试验，优选膏方制备工艺。结果 4种不同辅料膏方的制备工艺分别为红糖：A₁ 18%～23%、B₁ 1.210～1.260、C₁ 1.310～1.360；鹿角胶：A₂ 14%～16%、B₂ 1.200～1.250、C₂ 1.230～1.270；龟甲胶：A₃ 12%～15%、B₃ 1.190～1.230、C₃ 1.210～1.240；阿胶：A₄ 5.0%～8.0%、B₄ 1.190～1.220、C₄ 1.190～1.220。结论 优选的不同辅料的膏方制备工艺参数均准确可行，质量符合要求。

Objective To explore the best parameter in the preparation technology of paste with different adjuvants. Methods The appearance, the paste rate, and herb detection were selected as composite indicators. The multi-index comprehensive score method was used to evaluate the paste formability. Central composite design was used to optimize the preparation technology of paste by taking the adjuvant amount (A), the relative density of extract (B) and refined paste (C) as factors. Results The best condition in the paste preparation process with different adjuvants was as follows: brown sugar (A₁ 18%—23%, B₁ 1.210—1.260, and C₁ 1.310—1.360), Cervi Cornus Colla (CCC, A₂ 14%—16%, B₂ 1.200—1.250, and C₂ 1.230—1.270), Testudinis Carapacis et Plastri Colla (TCPC, A₃ 12%—15%, B₃ 1.190—1.230, and C₃ 1.210—1.240), Asini Corii Colla (ACC, A₄ 5.0%—8.0%, B₄ 1.190—1.220, and C₄ 1.190—1.220). Conclusion The parameters in the preparation technology of the paste with different adjuvants are accurate and feasible and the quality meets the requirement.