[关键词]
[摘要]
目的 研究中国台湾传统中药材小叶山葡萄Vitis thunbergii var. taiwaniana的化学成分。方法 利用大孔树脂、Sephadex LH-20、ODS及正相硅胶柱等色谱手段进行分离,通过多种波谱学数据分析进行单体化合物的结构鉴定。结果 从小叶山葡萄60%乙醇提取物中分离得到12个化合物,分别鉴定为白藜芦醇(1)、trans-ε-viniferin(2)、(7R, 8R)-threo-4, 7, 9, 9′-tetrahydroxy-3, 3′-dimethoxy-8-O-4′-neolignan 7-O-β-D-glucopyranoside(3)、(7S, 8R)-urolignoside(4)、schizandriside(5)、vitisin A(6)、vitisin B(7)、davidiol A(8)、3, 5, 4′-trihydroxystilbene 4′-O-β-D-glucopyranoside(9)、蛇葡萄素C(10)、(7R, 8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside(11)、表儿茶素(12)。结论 化合物3~5为首次从葡萄属中分离,化合物8、9、11、12为首次从小叶山葡萄中分离。
[Key word]
[Abstract]
Objective To study the chemical constituents in Vitis thunbergii var. taiwaniana specially grown in Taiwan, China. Methods The compounds were isolated by repeated HP20 macroporous adsorption resin column combined with Sephadex LH-20, ODS, and silica gel column chromatography. Their structures were identified on the basis of extensive spectroscopic data analysis and by comparison of their spectral data reported. Results Twelve compounds were identified as resveratrol (1), trans-ε-viniferin (2), (7R, 8R)-threo-4, 7, 9, 9′-tetrahydroxy-3, 3′-dimethoxy-8-O-4′-neolignan 7-O-β-D-glucopyranoside (3), (7S, 8R)-urolignoside (4), schizandriside (5), vitisin A (6), vitisin B (7), davidiol A (8), 3, 5, 4′-trihydroxystilbene 4′-O-β-D-glucopyranoside (9), ampelopsin C (10), (7R, 8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (11), and epicatechin (12). Conclusion Compounds 3—5 are separated from the plants of Vitis L. for the first time, and compounds 8, 9, 11, and 12 are separated from V. thunbergii var. taiwaniana for the first time.
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[基金项目]
厦门市重大科技计划项目(3502Z20100006)