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[摘要]
目的 研究角果木属植物十雄角果木Ceriops decandra树皮的二萜类化学成分。方法 采用正反相硅胶色谱、高效液相色谱技术进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果 从十雄角果木树皮的95%乙醇提取物中分离得到13个二萜类化合物,分别鉴定为7, 13-松香二烯-3β-醇(1)、18-羟基-8, 11, 13-松香三烯-7-酮(2)、8, 11, 13-松香三烯-3, 7-二酮(3)、3β-羟基-8, 11, 13-松香三烯-7-酮(4)、15, 18-二羟基-8, 11, 13-松香三烯-7-酮(5)、8, 11, 13-松香三烯-7β, 18-二醇(6)、8, 11, 13-松香三烯-3β, 18-二醇(7)、8, 11, 13-松香三烯-7α, 18-二醇(8)、13β-羟基-8(14)-松香烯-3, 7-二酮 (9)、13β, 18-二羟基-8(14)-松香烯-7-酮(10)、ent-8(17), 13E-半日花二烯-15-醇(11)、ent-8(14)-海松烯-15R, 16-二醇(12)、(5S*, 8S*, 9S*, 10R*, 13S*)-3-hydroxy-16-nor-2-oxodolar-3-ene-15-oic acid(13)。结论 所有化合物均首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from the barks of Ceriops decandra. Methods Various chromato- graphic techniques, including silica gel column chromatography and HPLC, were used. The structures of the compounds were identified by means of spectroscopic and chemical data. Results Thirteen diterpenoids were identified as 7, 13-abietadien-3β-ol (1), 7-oxodehydro-abietinol (2), margocin (3), 3β-hydroxy-abieta-8, 11, 13-trien-7-one (4), 15, 18-dihydroxyabieta-8, 11, 13-trien-7-one (5), 7β, 18-dihydroxy-dehydroabietanol (6), 4-epi-triptobezene L (7), 7α, 18-dihydroxydehydroabietanol (8), sabiperone E (9), 13β, 18-dihydroxy-abiet-8(14)-ene-7-one (10), ent-labd-8(17), 13E-dien-15-ol (11), ent-8(14)-pimarene-15R, 16-diol (12), and (5S*, 8S*, 9S*, 10R*, 13S*)-3-hydroxy-16-nor-2-oxodolar-3-ene-15-oic acid (13), respectively. Conclusion All the compounds are obtained from this plant for the first time.
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[基金项目]
广东省重大科技专项“珍稀红树植物及其内生真菌来源的靶向性天然化合物库的构建与创新药物研发”(2011A080403020,2012-2014)