目前指纹图谱已成为国际公认的控制中药或天然药物质量的有效手段。近年来对中药指纹图谱进行了很多探索性研究，但是真正将指纹图谱作为质量标准的只有中药注射剂，而其他的中药指纹图谱研究多只停留在研究阶段。造成中药指纹图谱研究瓶颈的原因很多，如天然产物成分的复杂性，指纹图谱的分析结果中往往有大量的杂质峰群存在，而现有的分析手段很难使这些杂质峰群达到很好的分离，为此提出了构建“区间指纹图谱”。对“区间指纹图谱”构建程序、建立方法、构建模式、应用问题等进行了较全面地研究和分析，并以神安颗粒为例进行了分析。

At present, fingerprint has become an effective mean recognized internationally in controlling the quality of Chinese materia medica (CMM) or natural products. In recent years, there are some exploratory studies on the fingerprint of natural product, while only the injection of CMM has taken the fingerprint as one of the quality criteria. Other fingerprint studies on natural products were all staying in the researching phase. There are many reasons for the bottleneck of natural product fingerprint research, such as the component complexity of natural product. There are always a lot of impurity peaks in the analytic result of fingerprint, while it is very difficult to dissociate these impurity peaks by forthcoming analytic methods. Therefore we propose to construct the “interval fingerprint”. The studies and analyses on the construction program, approach, model, and application problem of the “interval fingerprint” have been carried out with Shen’an Granule as the example.