目的 研究我国特有属药用植物裸蒴Gymnotheca chinensis的化学成分。方法 通过硅胶柱色谱及高效液相制备色谱分离纯化，以波谱分析和化学方法鉴定结构。结果 从裸蒴全草乙醇提取物中分离得到了一个苯酚衍生物，鉴定为 (7R)-苯甲酸-7-对羟苯基-乙二醇-8-单酯。结论 该苯酚衍生物为首次报道的新化合物，命名为裸蒴酚甲。

Objective To study the chemical constituents in Chinese endemic herb Gymnotheca chinensis. Methods The ethanol extract of the whole plant was separated by silica column chromatography, as well as preparative HPLC. The structure elucidation was based on spectroscopic and chemical analyses. Results A novel phenol derivative was isolated and identified as (7R)-7-[(p-hydroxyl)- phenyl]-ethyleneglycol-8-monoethyl benzoic acid ester (1) by using intensive 1D and 2D NMR spectra and chemical transformation. Conclusion Compound 1 is a novel phenol derivative named gymnothol A.

国家自然科学基金资助项目（30973634）