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[摘要]
目的 研究锦灯笼Physalis alkekengi var.franchetii根和茎的化学成分。方法 利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化,通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果 分离得到10个化合物,分别鉴定为β-谷甾醇(1)、胡萝卜苷(2)、木犀草素(3)、木犀草素-7-O-β-D-葡萄糖苷(4)、异岩藻甾醇(5)、硬脂酸单甘油酯(6)、睡茄内酯A(7)、胡萝卜苷-6′-O-硬脂酸酯(8)、齐墩果酸(9)、(Z)-9,10,11-三羟基-12-十八碳烯酸(10)。结论 化合物6、8、10为首次从该属植物中分离得到,化合物5、7、9为首次从该植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents in the roots and stems of Physalis alkekengi var.franchetii.Methods The constituents were isolated by chromatography on silica,Sephadex LH-20 gel columns,medium pressure and semi-preparative HPLC and their structures were elucidated by chemical properties and spectroscopic analyses.Results Ten compounds were isolated and their structures were identified as β-sitosterol (1),daucosterol (2),luteolin (3),luteolin-7-O-β-D- glucoside (4),isofucosterol (5),glyceryl monostearate (6),withanolide A (7),daucosterol-6′-O-stearate (8),oleanolic acid (9),and (Z)-9,10,11-trihydroxy-12-octadecenoic acid (10).Conclusion Compounds 6,8,and 10 are obtained from the plants in this genus for the first time.Compounds 5,7,and 9 are obtained from this plant for the first time.
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